Corporate Social Responsibility Through an Economic Lens

Business leaders, government officials, and academics are focusing considerable attention on the concept of “corporate social responsibility” (CSR), particularly in the realm of environmental protection. Beyond complete compliance with environmental regulations, do firms have additional moral or social responsibilities to commit resources to environmental protection? How should we think about the notion of firms sacrificing profits in the social interest? May they do so within the scope of their fiduciary responsibilities to their shareholders? Can they do so on a sustainable basis, or will the forces of a competitive marketplace render such efforts and their impacts transient at best? Do firms, in fact, frequently or at least sometimes behave this way, reducing their earnings by voluntarily engaging in environmental stewardship? And finally, should firms carry out such profit-sacrificing activities (i.e., is this an efficient use of social resources)? We address these questions through the lens of economics, including insights from legal analysis and business scholarship.corporate social responsibility, voluntary environmental performance

Corporate Social Responsibility Through an Economic Lens

Business leaders, government officials, and academics are focusing considerable attention on the concept of "corporate social responsibility" (CSR), particularly in the realm of environmental protection. Beyond complete compliance with environmental regulations, do firms have additional moral or social responsibilities to commit resources to environmental protection? How should we think about the notion of firms sacrificing profits in the social interest? May they do so within the scope of their fiduciary responsibilities to their shareholders? Can they do so on a sustainable basis, or will the forces of a competitive marketplace render such efforts and their impacts transient at best? Do firms, in fact, frequently or at least sometimes behave this way, reducing their earnings by voluntarily engaging in environmental stewardship? And finally, should firms carry out such profit-sacrificing activities (i.e., is this an efficient use of social resources)? We address these questions through the lens of economics, including insights from legal analysis and business scholarship.Corporate Social Responsibility, Voluntary Environmental Performance

X-Ray Structural Analyses of Cyclodecasulfur (S10) and of a Cyclohexasulfur-Cyclodecasulfur Molecular Addition Compound (S6 · S10) [1]

Low temperature X-ray structural analyses of monoclinic single crystals of S10 and S6 · Si10 (prepared from the components) show that the cyclic S10 molecule exhibits the same D2 conformation in both compounds with bond distances between 203.3 and 208.0 pm, bond angles (α) between 103 and 111°, and torsional angles (τ) between 73 and 124°. The S6 molecule (site symmetry Ci) in S6 · S10 is very similar to the one in pure S6 (dSS = 206.2 pm, α= 103°, τ = 74°). All intermolecular interactions are of van-der-Waals type. The Raman spectrum of S6 · S10 can be explained by a superposition of the S6 and S10 spectra

Accuracy of DNA methylation pattern preservation by the Dnmt1 methyltransferase

DNA methyltransferase 1 (Dnmt1) has a central role in copying the pattern of DNA methylation after replication which is one manifestation of epigenetic inheritance. With oligonculeotide substrates we show that mouse Dnmt1 has a 30- to 40-fold preference for hemimethylated DNA that is almost lost after addition of fully methylated oligonucleotides. Using long hemimethylated DNA substrates that carry defined methylation patterns and bisulfite analysis of the methylation reaction products, we show a 15-fold preference for hemimethylated CG sites. Dnmt1 moves along the DNA in a random walk methylating hemimethylated substrates with high processivity (>50 sites are visited on average which corresponds to linear diffusion over 6000 bp). The frequency of skipping sites is very low (<0.3%) and there is no detectable flanking sequence preference. CGCTC sites tend to terminate the processive methylation of DNA by Dnmt1. Unmethylated DNA is modified non-processively with a preference for methylation at CCGG sites. We simulate the propagation of methylation patterns using a stochastic model with the specificity of Dnmt1 observed here and conclude that either methylation of several sites is required to propagate the methylation information over several cellular generations or additional epigenetic information must be used

BISMA - Fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences

<p>Abstract</p> <p>Background</p> <p>Bisulfite sequencing is a popular method to analyze DNA methylation patterns at high resolution. A region of interest is targeted by PCR and about 20-50 subcloned DNA molecules are usually analyzed, to determine the methylation status at single CpG sites and molecule resolution.</p> <p>Results</p> <p>The BISMA (Bisulfite Sequencing DNA Methylation Analysis) software for analysis of primary bisulfite sequencing data implements sequencing data extraction and enhanced data processing, quality controls, analysis and presentation of the methylation state. It uses an improved strategy for detection of clonal molecules and accurate CpG site detection and it supports for the first time analysis of repetitive sequences.</p> <p>Conclusions</p> <p>BISMA works highly automated but still provides the user full control over all steps of the analysis. The BISMA software is freely available as an online tool for academic purposes for the analysis of bisulfite sequencing data from both unique and repetitive sequences <url>http://biochem.jacobs-university.de/BDPC/BISMA/</url>.</p

An Integrated Material Flows, Stakeholders and Policies Approach to Identify and Exploit Regional Resource Potentials

Material flows in the construction and demolition (C&D) sector remain high in many countries. But, their changes or reductions are essential for successful circular economies. Existing material flow analyses do not cover regional characteristics, stakeholders and impacts of policy measures and interactions. We contribute a new, unprecedented way of integrating regional building and infrastructure material stock and flow modelling with stakeholders, policy measures, their impacts and mutual interactions. Stakeholders are considered with their objectives, influences, interactions, willingness to act, to cooperate or contribute to resource conservation. 31 policy measures are crystallized from literature and evaluated in two surveys regarding their expected impact, their bundling and temporal effects. The integrated bottom-up simulation model was tested for the federal state of Baden-Württemberg (Germany). The results show that until 2030 net stock piling can be expected and secondary raw materials from building stock will be sufficient to supply future recycling concrete production until 2030. Most effective policy measures are additional cost/taxes on primary resources, increased disposal fees and curriculae adaption. Bundling these leads to a combined RESPOT of 30.8%. The results are useful for political decision makers, educational institutions, disposal site operators as well as primary and secondary raw material extraction industries

Shrimp and conventional U-Pb age, Sm-Nd isotopic characteristics and tectonic significance of the K-rich Itapuranga suite in Goiás, Central Brazil

The Itapuranga alkali granite and Uruana quartz syenite are large K-rich EW-elongated intrusions, in the central part of the Neoproterozoic Brasília Belt, central Brazil. They are associated with Pireneus lineaments, which cut the regional NNW-SSE structures of the southern part of the belt. SHRIMP and conventional U-Pb data for the Itapuranga and Uruana intrusions indicate crystallization ages of 624 ± 10 Ma and 618 ± 4 Ma, respectively. Three zircon cores from the Itapuranga granite yielded U-Pb ages between 1.79 and 1.49 Ga. Sm-Nd TDM ages for both intrusions are 1.44 Ga and eNd(T) values are -5.1 and -5.7, suggesting the input of material derived from older (Paleo- to Mesoproterozoic) sialic crust in the origin of the parental magmas. Magma mixing structures indicate co-existence of mafic and felsic end-members. The felsic end-member of the intrusions is dominantly represented by crust-derived melts, formed in response to the invasion of Paleo/Mesoproterozoic sialic crust by alkali-rich mafic magmas at ca. 620 Ma. These intrusions are roughly contemporaneous with, or perhaps slightly younger than, the peak of regional metamorphism in the southern Brasília Belt. Their emplacement along the Pireneus lineament suggest a syn-tectonic origin for them, most probably in transtensional settings along these faults

Gill transcriptome response to changes in environmental calcium in the green spotted puffer fish

Abstract Background Calcium ion is tightly regulated in body fluids and for euryhaline fish, which are exposed to rapid changes in environmental [Ca2+], homeostasis is especially challenging. The gill is the main organ of active calcium uptake and therefore plays a crucial role in the maintenance of calcium ion homeostasis. To study the molecular basis of the short-term responses to changing calcium availability, the whole gill transcriptome obtained by Super Serial Analysis of Gene Expression (SuperSAGE) of the euryhaline teleost green spotted puffer fish, Tetraodon nigroviridis, exposed to water with altered [Ca2+] was analysed. Results Transfer of T. nigroviridis from 10 ppt water salinity containing 2.9 mM Ca2+ to high (10 mM Ca2+ ) and low (0.01 mM Ca2+) calcium water of similar salinity for 2-12 h resulted in 1,339 differentially expressed SuperSAGE tags (26-bp transcript identifiers) in gills. Of these 869 tags (65%) were mapped to T. nigroviridis cDNAs or genomic DNA and 497 (57%) were assigned to known proteins. Thirteen percent of the genes matched multiple tags indicating alternative RNA transcripts. The main enriched gene ontology groups belong to Ca2+ signaling/homeostasis but also muscle contraction, cytoskeleton, energy production/homeostasis and tissue remodeling. K-means clustering identified co-expressed transcripts with distinct patterns in response to water [Ca2+] and exposure time. Conclusions The generated transcript expression patterns provide a framework of novel water calcium-responsive genes in the gill during the initial response after transfer to different [Ca2+]. This molecular response entails initial perception of alterations, activation of signaling networks and effectors and suggests active remodeling of cytoskeletal proteins during the initial acclimation process. Genes related to energy production and energy homeostasis are also up-regulated, probably reflecting the increased energetic needs of the acclimation response. This study is the first genome-wide transcriptome analysis of fish gills and is an important resource for future research on the short-term mechanisms involved in the gill acclimation responses to environmental Ca2+ changes and osmoregulation.Peer Reviewe

Marking and Quantifying IL-17A-Producing Cells In Vivo

Interleukin (IL)-17A plays an important role in host defense against a variety of pathogens and may also contribute to the pathogenesis of autoimmune diseases. However, precise identification and quantification of the cells that produce this cytokine in vivo have not been performed. We generated novel IL-17A reporter mice to investigate expression of IL-17A during Klebsiella pneumoniae infection and during experimental autoimmune encephalomyelitis, conditions previously demonstrated to potently induce IL-17A production. In both settings, the majority of IL-17A was produced by non-CD4+ T cells, particularly γδ T cells, but also invariant NKT cells and other CD4−CD3ε+ cells. As measured in dual-reporter mice, IFN-γ-producing Th1 cells greatly outnumbered IL-17A-producing Th17 cells throughout both challenges. Production of IL-17A by cells from unchallenged mice or by non-T cells under any condition was not evident. Administration of IL-1β and/or IL-23 elicited rapid production of IL-17A by γδ T cells, invariant NKT cells and other CD4−CD3ε+ cells in vivo, demonstrating that these cells are poised for rapid cytokine production and likely comprise the major sources of this cytokine during acute immunologic challenges